Description
Product Characteristics:
Subcellular location: Cytoplasm, Nucleus
Synonyms: FLFL1, KIAA2010, MEK1 SUPPRESSOR 1, MSTP033, P4R3A_HUMAN, PP4R3 ALPHA, PP4R3A, PPP4R3A, PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA, Serine/threonine-protein phosphatase 4 regulatory subunit 3A, SMEK homolog 1, SMEK homolog 1, suppressor of mek1 (Dictyostelium), smek1, SMK1.
Target Information: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair